The SUV went out of control at more than 100 miles per hour and overturned on Texas Highway 85, ejecting those inside, Dimmit County Sheriff Marion Boyd said.
Dimmit County Sheriff Marion Boyd told the outlet another five passengers were rushed to San Antonio Military Medical Center for emergency care.
This SUV was packed with undocumented immigrants as it crashed trying to escape border patrol.
Representatives for both U.S. Customs and Border Protection and the Dimmit County Sheriff's Office did not immediately respond to HuffPost's request for comment.
The passenger, also believed to be a USA citizen, is now in custody.
Twelve people were ejected from the vehicle.
Four people were killed at the scene about 50 miles from the Mexico border and a fifth person died at a hospital in San Antonio, the sheriff said.
SUV fleeing border control crashes in Texas, killing 5
The crash took place in the city of Big Wells outside San Antonio after Border Patrol agents tried to stop the driver of an SUV, ABC television affiliate KSAT reported.
In all, 14 people were inside the SUV, including the driver and passenger, according to the sheriff. The vehicle was traveling around 100 miles per hour, according to Boyd.
The sheriff said he hadn't spoken to Border Patrol on the exact cause of the pursuit and nature of the crash.
"We've seen this many, many times", Boy said.
The Border Patrol said in a statement Sunday night that two other vehicles had been travelling alongside the SUV earlier in the day.
He added: 'This is a ideal example of why our borders need to be secure'.