Nonetheless, Barca took a 2-1 lead through Lionel Messi before Gareth Bale got the second equaliser as it ended 2-2 on the night.
The game ended 2-2, but Ronaldo was hauled ashore after 45 minutes, injuring himself while scoring the goal.
Addressing the injury, via MARCA, Zidane admitted Ronaldo's ankle was "swollen" but backed his superstar to recover quickly.
Cristiano Ronaldo falls on Barcelona's Spanish defender Gerard Pique as he scored.
"We had a good opportunity to win today, clearly, we had a lot of chances to score, especially in the first half". Right now it's not good, but it's going to be minor. He said it wasn't much, but we'll see tomorrow, we'll do some tests to see the extend of the damage done to his ankle.
Speaking after the game, however, Real manager Zinedine Zidane said "we're not anxious about the final", but added that "I can't say how long he'll be out for".
Zidane's decision to bring Marco Asensio for the five-time Ballon d'Or victor raised eyebrows and concern over his fitness with the upcoming UEFA Champions League final against Liverpool and the 2018 FIFA World Cup.
Real Madrid will now lock horns with Sevilla in their next La Liga clash on May 10 before they head into their Champions League final match against Liverpool on May 27. The ESPN FC crew delve into the controversial decisions in El Clasico that saw the derby end in a 2-2 draw.
'Champions League? We're going to do everything to make it'.
"Everyone who likes football can be happy with a game like that".