All three goals were scored in a insane eight-minute spell, but Mark Hughes has now charged his side to go for the kill.
United is second behind newly crowned champion Manchester City, and Mourinho is on course to deliver the club's highest finish since Alex Ferguson retired in 2013.
Spurs, who are using the national stadium this season while their new 61,500-seater stadium is being built, have turned Wembley into a fortress, suffering just two Premier League defeats there all season, and beating Borussia Dortmund, Real Madrid, Liverpool, Arsenal and United. The intensity was there from the off, the atmosphere generated momentum, and they made it count as soon as they could. Davinson Sanchez aimed a long, hopeful ball down the right flank, catching Ashley Young horribly out of position and Pogba off guard. "When you play away from home the supporters were phenomenal". Could that give Mauricio Pochettino's men the edge? Staying cool, calm and collected, he rarely gets caught up in the moment. Equally as telling, though, was the dejected look on his face when Herrera netted the second to turn the game on its head.
The defeat means Tottenham have now gone 10 years without winning a major trophy, with the the 2008 league cup their only triumph since lifting the FA Cup in 1991.
I just don't see it being a feast of football this time, and Mourinho will not want an open game.
"I think the second half was quite calm because we were with the feeling that it was going to be very hard to lose the game, and most probably we would win it". "But it's different to when we play in the Premier League".
Reacting quickly, Tottenham nearly took a lead into the break themselves when Eric Dier struck a low effort from long range, the ball taking a deflection off Chris Smalling before coming back off the post.
Danny Rose remains sidelined by a calf issue and Harry Winks is a long-term absentee with an ankle problem.