The France global joined Arsenal from Lyon last summer for a then club record fee of £46.5million, but hasn't produced as many goalscoring moments as Arsene Wenger would have liked over the past few months - but his past two games have showed that he is more than capable of leading the Gunners to Europa League glory, following an impressive brace and performance against CSKA Moscow.
Within the opening minutes it was clear that is was set to be a battle of the two attacking units and not their defence.
Before the quarter-of-an-hour mark had passed however, the visitors were level.
It got better for the hosts on 28 minutes when Ramsey bagged his second and Arsenal's third with a lovely chip over the on-rushing Akinfeev after being played in by Ozil. Lacazette stepped up to send Akinfeev the wrong way to re-assert the Gunners' lead. They are a strong side.
The Armenian midfielder brought a frustrating spell at Old Trafford to a close during the January transfer window when he completed a switch to Emirates Stadium. The Welshman had the ball in the back of the net but it wouldn't count.
Arsenal will hope that this side isn't CSKA Moscow.
Arsenal regained their composure lost having conceded the equaliser and were soon back in front as Ozil was tripped in the penalty area by Georgi Schennikov.
The Armenia global then drew a smart save out of Akinfeev, with Ramsey blazing the rebound over as he went in search of a second hat-trick of the season.
It was then Lacazette's chance to bag his triple but missed a golden opportunity to complete his hat-trick. He was always adamant - "I'm OK, I'm OK" - but players are like that.
Arsenal now goes into next Thursday's second leg in the Russian capital in a commanding position.