The supporting actor Oscar favourite Sam Rockwell (Three Billboards Outside Ebbing, Missouri) added to his string of awards.
Women and minorities walked away with the majority of the awards on Saturday, including Tatiana Riegel, the first woman to be nominated for a Best Editing Award, who took home the prize for her tight, compelling edit of "I, Tonya".
"I continue to be amazed you let me get to the microphone", McDormand said.
The prize for best actor went to American-French rising star Timothee Chalamet, whose acclaimed performance as a lovelorn teen in Call Me By Your Name has seen him win numerous awards.
"Like with Kevin Spacey: Can we still love K-PAX?"
"What about Woody Allen and his last 20 unwatchable movies?" "Can we still not watch them?"
"I play a lot of confused and complicated women, but not anyone this dark". As was previously announced, Film Independent's Robert Altman Award, given every year to honor an ensemble and its casting directors, went to Dee Rees' Netflix pic "Mudbound".
Get Out wins Spirit Award on eve of Oscars
Much of the ceremony is often spent celebrating the passionate and thrifty art of independent film.
Kumail Nanjiani and Emily V. Gordon won best first screenplay for The Big Sick, which they based on the real-life drama of the beginning of their own relationship. The two are also nominated for an Oscar in the same category. They both thanked their parents, who provided some of the inspiration for the parents in the film, with some artistic license. "That was something we made up for the movie". The Best First Feature award was given to Neon's "Ingrid Goes West", while the global prize went to Sony Pictures Classics' "A Fantastic Woman". Sebastián Lelio's A Fantastic Woman, from Chile, won best worldwide film. Five out of six of the Best Feature wins have gone on to win the prestigious Best Picture award, putting Get Out firmly back in the race.
"I thought the film was going to encounter, to say the least division, and that hasn't been the case", Lelio said backstage. "So, now I gotta worry a little bit more." .
The Rider director Chloe Zhao was given the inaugural Bonnie Award, for a mid-career female director, which includes a $50,000 grant.
The last major annual awards show before the Oscars, the Independent Spirit Awards has historically been a pretty accurate prediction of which film would go on to win big at the next day's Academy Awards.
In addition to producing the Spirit Awards, Film Independent produces the LA Film Festival and Film Independent at LACMA Film Series, a year-round, weekly program that offers unique cinematic experiences for the Los Angeles creative community and the general public.