Kick-off was delayed by four minutes as Frankfurt fans were allowed into the area between the stands and the advertising boards to protest.
Particularly in the National Football League, fans and players have grown annoyed with Monday and Thursday night games. In response to the controversial scheduling decision, Frankfurt fans organized an in-game protest.
Timothy Chandler and Kevin-Prince Boateng cancelled out Jean-Kevin Augustin's early strike as Frankfurt overtook Leipzig to go third, and deny the visitors the chance to reclaim second.
"It was peaceful and then everyone went back". Few Leipzig fans were there to celebrate.
Even when Boateng fired Frankfurt in front on 26 minutes, the celebrations remained muted as the protests continued. Leipzig were awarded a penalty when Rebic appeared to tangle with Sabitzer - but yet again this weekend VAR was consulted and ruled against the award of the penalty, despite replays suggesting a tangle of legs in the box that would have warranted a spot-kick.
Leipzig coach Ralph Hasenhuettl responded with sarcastic applause.
The second half was also delayed as Frankfurt fans launched toilet paper and tennis balls onto the pitch.
Frankfurt were apparently aware in advance of the action as a large team of helpers came out to clear the pitch.
"As a Bundesliga club, we have to accept this and be able to deal with protest culture", Frankfurt board member Axel Hellmann had told regional television station Hessische Rundfunk in the build-up to the match.
With the Frankfurt fans making the atmosphere as hostile as possible, the second half was a lot scrappier as the yellow card count mounted to eight, with six of those for Frankfurt players. His final whistle finally ended the fans' whistling.