Fournette and the Jaguars will head to Pittsburgh to take on the Steelers for a chance to play for the AFC Title. Without McCoy, the run-first Bills would be forced to turn to Mike Tolbert, shifting a ton of the pressure onto the arm (and legs) of quarterback Tyrod Taylor and creating a much more hard set of circumstances.
Bills backup Nathan Peterman came in and threw an interception as Jaguars cornerback Jalen Ramsey made a diving catch to seal the game.
The Jaguars took a 10-3 lead with 42 seconds left in the third quarter.
Bortles is 11 of 21 for 85 yards while Fournette has 55 yards on 14 carries.
According to oddsmakers from online sports book Bovada.lv, the Jaguars are 8.5-point home favorites to beat the Bills, who opened as 7.5-point road underdogs when the line was first released for this game. The drive culminated in Blake Bortles' 1-yard touchdown pass to Ben Koyack with 49 seconds remaining in the quarter. He was 6-of-15 passing for 33 yards. McCoy rushed for 1,138 yards and six scores on the season, helping Buffalo to a shocking postseason berth with a 9-7 record.
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Taylor will face a Jacksonville team that sacked opposing quarterbacks on 9.3 percent of dropbacks, which was also the second-highest rate in the league. But receiver Kelvin Benjamin was called for offensive pass interference in the end zone.
The Jaguars managed just 27 yards in the first quarter.