"There is no more fatal blunder than the miscalculation that the U.S. and its followers could check by already worn-out "sanctions" the victorious advance of our people who have brilliantly accomplished the great historic cause of completing the state nuclear force", the ministry said.
The U.N. Security Council unanimously approved tough new sanctions against North Korea on Friday in response to its latest launch of a ballistic missile that Pyongyang says can reach anywhere on the USA mainland.
The North Korean Foreign Minister has stated that the country will continue to develop its nuclear program "for self-defense purposes" to protect itself from "hostile" acts by the US.
The new punitive measures included in the United Nations resolution will significantly cut short refined petroleum exports to Pyongyang, put a lid on its crude oil imports, ask United Nations member states to repatriate North Korea nationals earning incomes overseas, and crack down on ships illegally transferring oil to or smuggling banned items from the country.
In a statement carried by the official KCNA news agency, North Korea's foreign ministry said the United States was terrified by its nuclear force and was getting "more and more frenzied in the moves to impose the harshest-ever sanctions and pressure on our country".
The new resolution is tantamount to a complete economic blockade of North Korea, the ministry said.
The statement said that Pyongyang aims to further consolidate its nuclear deterrence aimed at eradicating USA nuclear threats and blackmail by establishing a balance of force.
"The US and its puppet followers should never forget the newly-upgraded status of our nation as a nation that could pose a real nuclear threat to the US mainland", it added.
North Korea said those who voted for the sanctions would face Pyongyang's wrath.
A Foreign Ministry spokesman said the USA -led sanctions are a "grave infringement" on the sovereignty of the country and insisted that its nuclear weapons are a "self-defensive deterrence that does not contradict any worldwide law".
The UN Security Council unanimously approved the sanctions in response to North Korea's latest launch of a ballistic missile that Pyongyang says can reach anywhere on the USA mainland.