Madrid's next match is a tough visit to crosstown rival Atletico Madrid on November 18 after the global break.
"Bale breaks down again", splashed the front page of Madrid sports daily AS.
Bale's latest injury is a strain to his adductor muscle, as confirmed in the medical report shared by Real Madrid.
Indeed, including Bale's bumper salary, AS believe his 159 games for the club have cost Madrid 1.06 million euros a match.
Isco admits that Real Madrid teammate Gareth Bale "is having a hard time", having been ruled out of action for a further month or so. With Real Madrid struggling this season - they trail Barcelona by eight points already - his return was seen as crucial to helping them turn things around.
However, for many in Madrid those moments have been far too fleeting for the club's record purchase.
Bale has made just seven appearances in all competitions under Zinedine Zidane this season, netting three goals and chipping in with three assists.
Injuries have hampered the 28-year-old's impact at the Bernabeu.
"In fact, players like Isco or Asensio with their performances continually put his place in the team in doubt".
The Wales global has sustained another injury setback and is expected to be out for close to a month.
The potential of former Tottenham Hotspur winger Gareth Bale always seems to remain unfulfilled at Real Madrid.