Last chance for Messi and Argentina to make it to the FIFA World Cup 2018 in Russian Federation, when they will face Ecuador in a must win game tomorrow (Wednesday). Ecuador away won't be an easy match for Argentina considering the massive pressure and the fact that the match is played at 2,850 metres in the thin air of Quito. After a 0-0 draw with Peru last time out, they need a win in Ecuador on Tuesday to have a chance of qualifying automatically.
From South America, top point holder four teams will play 2018 Russia World Cup directly and fifth ranked team will have to pass the play off round which will be against New Zealand.
Colombia hasn't lost a World Cup qualifier in Peru since 1981 and if they can avoid defeat on Tuesday they'll likely be headed to Russian Federation. Argentina now sit in sixth place, level on points with fifth place Peru and one point behind third and fourth place Chile and Colombia.
Beleaguered coach Jorge Sampaoli - the third of the qualifying campaign - has called on his players to follow Messi's example.
The phrase 'must-win-match' is often used premiscuously. Brazil have already qualified for Russian Federation on 38 points, while Uruguay (28) need just a draw from their final game against Bolivia to advance.
"Messi is extraordinary but he is yet to win a World Cup", he told newspaper La Nacion.
Hello and welcome to the crucial World Cup qualifier between Ecuador and Argentina.
In addition, a Brazil victory against Chile could aid Argentina in possibly grabbing an automatic qualification spot.
When asked about the prospect of Messi missing the World Cup, Jesus replied: "Messi is one of the game's greatest-ever players but we are just thinking about ourselves". Brazil was the first country to qualify for next summer's World Cup. The 53-year-old has named a relatively inexperienced squad, with just eight of players plying their trade outside Ecuador.
Chile travel to Brazil for their last match, as Peru host Colombia.
Sampaoli, who took over in June and has yet to record a competitive win, has not named his side for the match but Lionel Messi is sure to start. They need favours from everywhere.
A draw for Messi and company could be enough, depending on how other results fall.