As such, Alcon Entertainment, Sony Pictures, and Warner Bros.
Its 163-minute running time, limiting the number of screenings, was said to be one factor in the under-performance.
Meanwhile, horror movie It showed plenty of staying power to claim third place with US$9.6 million.
This piles onto a long line of box office clunkers this year, adding it to the list of King Arthur: Legend of the Sword, Valerian and the City of a Thousand Planets, The Dark Tower, and others.
Blade Runner 2049 sees Harrison Ford reprising the role of Rick Deckard alongside Ryan Gosling, Ana de Armas, Sylvia Hoeks, Robin Wright, Mackenzie Davis, Carla Juri, Lennie James, Dave Bautista, Jared Leto and Edward James Olmos. The audience was mostly male (71%) and overwhelming older than 25 (86%).
Predictions last week had Blade Runner 2049 heading closer to the $50 million mark so investors are bound to be a little caught off guard, especially considering the overwhelmingly positive reviews it received. "Where we did do business was in the major markets". "Alcon and Denis made an awesome movie. The audience for it was narrower than we anticipated". Focus Features' expansion of Judi Dench's "Victoria & Abdul" came in 8th with $4.2 million at 732 locations.
That tally was higher than the $44.6m for The Martian, starring Matt Damon, on its opening weekend in 2015. Reviews have been mixed, earning the film a 46 per cent score on Rotten Tomatoes.
With all these theatrical releases, the action film Kingsman: the golden circle has fallen from first to fifth place with revenue of $ 8.7 million in three days and 80 million dollars in three weeks.
Coming out of the weekend, however, the film only took in $31.5 million, a major disappointment for the film and its studio Warner Bros.
United Kingdom moviegoers have been its biggest fans, spending $40.7m (£31.1m) on tickets since its release on 8 September.