Many have started to compare the Spurs front-man with the iconic La Liga duo, and growing numbers are expecting him to one day overtake Alan Shearer as the all-time leading scorer in the Premier League.
Kane, who now has 21 goals in his last 10 away games for club and country, was brought off to a warm ovation from the entire ground, robbing him of the chance to score a second hat-trick in a week.
Kane, with his back to goal and two defenders nearby, shrugged off their attention, swivelled and hit a wonderful curling effort past Lossl from 25 yards.
Kane grabbed his brace in the 23rd minute as he evaded the challenges of two markers and curled a left footer to the far corner.
When Kane was substituted in the closing stages, most of the home fans stood to applaud: sometimes recognition of brilliance trumps partisanship.
"I am so happy with everyone because we played in the Champions League in Cyprus, arrived late and came here and showed energy, so that performance was fantastic for us".
The win moved Spurs up to third in the league and it's fair to say their players are all moving to the same beat at the moment, but how did they each get on as individuals? It makes me very proud about everyone - coaching staff and staff - because we are working hard to try to help the team win games and we did.
Thirteen is also the most Ronaldo has managed in a month, the Real Madrid forward doing so in October 2010, while Barcelona superstar Messi matched that number in March 2012, with Kane's rampant run lending credence to the argument that he deserves to be mentioned among the best in world football.
After nine minutes, Huddersfield's Chris Lowe was caught napping at the back, the England striker raced through on goal and calmly slotted past Jonas Lossl to put Spurs ahead. "We probably won't be up against each other much in the game but it's always great to play the best in the world", the English worldwide said. "It's nice, I feel good, I feel confident".
However, the Danish global returned to training 48 hours later, and Pochettino is counting on him when Spurs visit Huddersfield.
This will be the first Premier League meeting between the two sides.