Spurs will be looking to bounce back from their disappointing loss to the Hammers in their league match against Manchester United at Old Trafford on Saturday.
Jose Mourinho's men have lost bit of their momentum over the last few weeks and the Manchester United manager was not impressed with his team's attitude in their defeat to Huddersfield last weekend.
"I don't speak about injured players, so don't ask me about Harry Kane", the Portuguese added, before listing United's own lengthy injury list.
Meanwhile, Tottenham are also likely to be without top scorer Harry Kane for the tie at United.
"(If) I speak about him, I have to speak about Zlatan Ibrahimovic, (Marouane) Fellaini, (Paul) Pogba, (Marcos) Rojo, (Michael) Carrick - so I don't speak".
"We will see after for Wednesday and Real Madrid, but for tomorrow, it's impossible".
Arsenal will be comfortable at the Emirates when they receive Swansea in what should provide them with much needed three points. but there are no easy fixtures in the EPL and Swansea are capable of producing a shocker.
However a double from Andre Ayew restored parity for West Ham before Angelo Ogbonna headed home the victor to end Tottenham's chances of adding to their four League Cup titles, the last of which came in 2008.
"I have the player that I want to have", Mourinho said.
It's a huge game and the crowd will really be up for it, but if you go after Tottenham they can get you.
Expect a slightly pragmatic approach from the hosts yet again, although they are unlikely to be overly defensive against a Kane-less Tottenham.