The opening scene highlighted Cruise's Ethan Hunt clinging to an Airbus 400 as it navigated down a runway and in the end takes off.
The risky stunt was performed today, and soon after, the star began limping, worrying his staff and crew.
After hoisting himself onto the building, Cruise limps before collapsing near crew members.
In the footage, the impact looks serious and, once delivered by wire to the roof, Cruise limps away, unsteady on his feet.
This mission wasn't quite possible for Tom Cruise.
While the complete details are a bit murky at time of reporting, what's clear is that Cruise's injury could affect the filming schedule for Mission: Impossible 6 and, furthermore, it could affect the film itself.
"I've trained for 30 years doing things like this", he said back in 2013 on The Graham Norton Show.
The question that remains in many fans' minds regards why Cruise would risk injuring himself for the Mission: Impossible movies. "He said that's why he does it; it's all about entertaining an audience and it makes the movie better". The extent of his injuries or the seriousness of the mishap was not immediately clear.
"Plus, you want to live through it".
"Mission: Impossible 6", starring Cruise as International Monetary Fund agent Ethan Hunt, is scheduled to be released July 27, 2018.