Those flights included trips on all five space shuttles-Columbia, Challenger, Discover, Atlantis and Endeavor-and missions aboard the Russian Space Station Mir and the International Space Station.
Aboard the space station, the three astronaut will be joined by Expedition 52 Commander Fyodor Yurchikhin of Roscosmos and Flight Engineers Peggy Whitson and Jack Fischer of NASA. It was 9:41 p.m. local time at the launch site.
The Citadel also will stream the launch on its Facebook page.
NASA will start sending astronauts up to the station using ships developed by SpaceX and Boeing by the end of next year. He performed two spacewalks during that mission.
The European Space Agency shared a video of the launch online. His science mission for ESA is called Vita (short for Vitality, Innovation, Technology and Ability) and was selected by Italy's ASI space agency. The latter three have been studying how microgravity impacts cancer therapies since April, and have been measuring the composition of meteors orbiting Earth's atmosphere.
"The trio will take a six-hour, 19-minute ride from Earth to the station's Rassvet module", NASA wrote in a blog update.
The soon-to-be six crew members of Expedition 52 will continue work on hundreds of experiments in biology, biotechnology, physical science and Earth science aboard the International Space Station.
NASA shared a video of the crew as they reached orbit.