A firefighter, Lt. Dennis DeVoe, was rushing to the station to respond to the alarm when his auto was hit by a woman who allegedly drove a stolen vehicle through a stop sign while under the influence.
The firefighter was rushed to hospital but died of his injuries.
Investigators are still looking into a hoverboard that is believed to have sparked a house fire over the weekend.
Officials say the hoverboard was plugged in and charging before it caught fire.
On Friday night, fire crews were called to a burning house in Harrisburg, Pennsylvania.
The little girl died the next morning at the Lehigh Valley Hospital Burn Center. Two other females were rescued by ladder from the ground, as was a man.
Khanyae Kendall, 19, fled the scene on Friday evening but was later arrested and has been charged with driving under the influence and aggravated assault among others.
Lt. Dennis DeVoe of Stewartstown, a 21-year veteran of Harrisburg Fire Department, died at Penn State Hershey.
Authorities said one victim jumped from a second-floor porch roof to escape the flames.
The coroner said Hughes was three years old.
"My granddaughter, I can't replace her", said Mark Hughes, who went to the scene of the fire Saturday and spoke exclusively to FOX43. "The pain is deep". The vehicle he was driving had been reported as stolen. Two girls remain hospitalized in critical condition.
Fire Chief Enterline said the fire that killed the toddler in Harrisburg was ruled as accidental.
The district attorney said further charges are subject to an autopsy and a formal investigation.
DeVoe, of Stewartstown, was a career firefighter for the Harrisburg Bureau of Fire, and also volunteered with fire companies in Fawn Grove and Whiteford, Harford County, Maryland.
"I'm so hurt. I'm hurt".
"Maybe this is what takes us to the next level and there comes some federal mandates down and we make this better for everybody", he added. The fire chief described DeVoe as "a leader in our department and the fire service as a whole".