The company announced on Friday that it will close the store in the New River Valley Mall in Christiansburg and at Tanglewood Mall in Roanoke County.
The Indianapolis area has survived another round of store closures by J.C. Penney Co., but the rest of the state didn't escape unscathed.
Penney's is one of a number of stores scaling back its store footprint as shoppers increase their online shopping.
Belk, another of the anchor stores at Georgia Square, also recently renewed its lease, according to mall marketing director Monica Hawkins.
Longtime mall staple J.C. Penney released a list Friday of 138 upcoming store closures, a move that will impact about 5,000 employees across the country. The company will offer outplacement support services for eligible associates leaving the company. Most affected stores will begin liquidating inventory on April 17.
The J.C. Penney location in the Morgantown Mall, 22 miles away from Uniontown, is also not slated for closure. Now, it has unveiled a new round of layoffs that will result in 140 stores closing down.
In January, Macy's said it was closing 68 stores, including one at CityPlace in West Palm Beach, as part of a 100-store purge announced in August 2016. The Penney store served Midland from 1939 until March 26, 1954, when fire demolished the Reinhart building, destroying the Penney's store, other business establishments and professional offices.
J.C. Penney said the stores that are closing make up about 14 percent of its total store count but represent only about 5 percent of total sales.
The decision to close stores was made after an analysis of store performance and local demographics, Thomas said.
"That is the unfortunate side of the retail industry, stores come and go, but we change and adapt with the times", she said.