Manchester United's progress to the Europa League quarter-finals was overshadowed by the world's most expensive footballer Paul Pogba's injury during their 1-0 win over Rostov here.
With his side having to play its next match - a league game against Middlesbrough away from home - at midday local time on Sunday, Mourinho has blasted organisers for failing to do more to accommodate England's top-flight teams when they are competing in Europe.
After three games matching up a back three against similar shapes, Mourinho may well decide to revert back to a 4-2-3-1 for Boro, with the midfield nearly picking itself due to the absences of Herrera and Pogba. Marcos Rojo was so depleted of energy during the game that he called for a banana to be brought on to the pitch. Both Anthony Martial and Wayne Rooney missed games against Chelsea in the FA Cup and FC Rostov in the UEFA Europa League. "Fatigue has a price". I think they don't give an "s" about English teams in Europe.
Mourinho has never spent more than three years as head coach at any club, but he hopes to last at least that long at United as he looks to restore their place at the summit of English football.
Pogba's night ended on a disappointing note early in the second half, going off with a suspected hamstring injury.
United visit the Riverside Stadium, needing a much needed win after drawing eight times in their 17-match unbeaten run in the league.
"If you were exhausted any time in your life, I was exhausted many times, I know what the body needs", said the Portuguese. "He was one of the players who never had a rest, because he played every game".
And while he did not go into details about the players he did not fancy, it is easy to draw conclusions from his treatment of Bastian Schweinsteiger and prompt release of Memphis Depay and Morgan Schneiderlin.
In an apparent reference to United's domestic fixture schedulers, Mourinho complained: "We have lots of enemies".
"Forget it, ' he said".
"It's a different challenge that I like because I'm assuming even more responsibility".
Netherlands worldwide Memphis Depay has revealed that he is not angry with Jose Mourinho or Manchester United after being forced to resurrect his career with Lyon in Ligue 1.
"I still think we can win a lot of games and get into the third or fourth positions".