The bariatric surgery was performed Tuesday in Mumbai on 1,000-plus-pound Eman Ahmed Abd El Aty, according to NDTV.
A spokesperson for the hospital said Abd El Aty was likely to lose more weight in the coming months.
Eman Ahmed, who arrived in India at the Saifee Hospital in Mumbai last month for treatment has undergone her first surgery after losing over 100 kilograms.
As per the statement issued by Eman's doctors, "Eman successfully underwent a Laparoscopic Sleeve Gastrectomy on March 7th 2017 at Saifee Hospital".
The 37-year-old Egyptian patient is taking oral fluids and "accepting them well".
For Ms Ahmed, the doctors hope to make her lose around 440 pounds in the next six months.
"Eman has lost over 100kg and has been shedding weight gradually on a daily basis with all the treatment and support", a spokeswoman for Dr. Muffazal Lakdawala, who has been leading the treatment, told AFP. "The 48 hours after surgery were crucial and we have crossed that period without any complications."Ms. Ahmed was lifted by crane and shifted from her special ward to Saifee Hospital's main building". With 400 kilos, she is far ahead of the current holder of the title, the American Pauline Potter, weighed to 293 kilos last July according to the Guinness Book of Records.
Abd El Aty was transported on a mini-truck to the airport, where she was flown on a chartered plane to India. Her weight has now been brought under 400kg since she arrived in Mumbai in early February.
Ms Abd El Aty's family says she weighed 5kg (11lb) at birth and was diagnosed with elephantiasis, a condition in which body parts swell due to a parasitic infection.
And by age 11, El Aty suffered a stroke because of her rapid weight gain, leaving her immobile.
Bariatric surgery, also known as weight loss surgery, is used as a last resort to treat people who are dangerously obese and carrying an excessive amount of body fat.