Jack Clifford has been named at openside flanker in England's side to face Wales on Saturday and forms part of an inexperienced back row with only 10 worldwide starts between them.
Clifford replaces Tom Wood, who has been relegated to the bench after suffering a shoulder injury in the uninspiring victory over France at the weekend.
England failed to impress during their opening match of the competition but still found a way to defeat France 19-16 at Twickenham. Maro Itoje, Jack Clifford and Nathan Hughes shared just 20 caps compared to their opposites' 130.
A cheap penalty conceded by the hosts allowed England to cut the deficit, with Farrell splitting the posts from 40 metres.
"It is going to take a huge game out of us to get a win, and it will be one of the biggest games of the Championship for sure".
They lost heavily to Australia in November and were criticised for their style of play in wins over Argentina, Japan and South Africa.
England have a poor record in Wales which suggests this will prove a hard hurdle for the side to maintain their winning run.
Jones was also clumsy in possession and knocked the ball on just before half-time as Wales were encroaching on England's line with a massive overlap.
Farrell missed the angled conversion attempt, yet, while England had served notice of their impressive forward power, Wales kept chipping away as a second Halfpenny penalty cut the deficit to two points. "You have to show a good example to the other players". When you look back, if someone asks where are the best places you've played, you would say the Millennium Stadium, for the atmosphere and everything that comes with it. We played with pace, we played with accuracy, as did England.
Nevertheless, Jones said: "We have a nice blend of experience and youth and we feel we have got the balance right".
"It's one of those traditional games and means so much to their supporters and to our supporters".
Evans and Francis bolstered Wales' scrum when they went on as replacements at Stadio Olimpico, so their appearance in the starting XV this time around is no surprise. They're things you can't control.
The Welsh notably tried to pull one over England in 2015, by delaying their arrival on the field long after England's.
Wales vs England Six Nations rugby is set to begin at 4.50pm GMT (5.50pm CET, 10.20pm IST). The latter are on offer at 10/11 getting a five-point start on the handicap, with the visitors 9/2 to come out on top by a margin of 1-5 points.
"But we'll take that, we'll bottle it and we'll use it in two weeks time when we go to Murrayfield". Mark my words, this is a very risky rugby team and we can't be loose.