Megyn Kelly is no longer the female face of Fox News.
Kelly's departure deprives Fox News of its second-most-watched host, behind only Bill O'Reilly.
The show will air Monday through Friday at a still-to-be-determined time.
Many of Megan Kelly's Facebook followers were angry after the TV news anchor posted she's leaving Fox for NBC.
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Rupert Murdoch and his sons James and Lachlan, who oversee Fox News and the rest of parent company 21st Century Fox, had worked hard to convince Kelly to stay within the company, offering her several different options.
Her 12-year stint with the network has been marked by upheavals and personal attacks on the campaign trail. The liberal media will expect Fox to put another female host in prime time.
We've been talking about Megyn Kelly a lot in recent months. An internal investigation at Fox News eventually turned up 20 additional women who claimed to have been harassed by Ailes over the years.
However much NBC spent, it will likely be worth it, as Kelly is one of the top draws of cable news. Kelly has become a major star through her dealings with Donald Trump.
Kelly's immediate silence after Gretchen Carlson's lawsuit last summer alleging unwanted advances from Ailes, at a time other Fox News personalities were supporting their boss, was telling. He upped the ante in August when, after Kelly called him out for his sexist statements about women during a Republican debate, he said Kelly had "blood coming out of her wherever". She also took aim at Trump and her colleagues in the book, saying that others at the pro-Trump network had tipped off the president-elect to critical questions during primary debates hosted by Fox.
The network did not immediately respond to a request for comment.