Fire officials said the century-old church was fully engulfed in flames, and sustained heavy heat, smoke and water damage.
The Delta Daily News reports that the fire happened at around 9:15 p.m. CT. Greenville Fire Chief Ruben Brown confirmed that there were no reported injuries and that most of the damage happened in the main sanctuary.
A press conference will be held this morning at 10:30 AM at Greenville Fire Department- Station 1 located downtown.
The Tuesday night fire heavily damaged the 200-member Hopewell Missionary Baptist Church in Greenville, Mississippi.
When asked whether he believed the act was racially motivated, the mayor said: "The black church has always been a symbol of the black community and more importantly of rights and civil liberties that were deprived from African Americans".
Simmons said that there haven't been any similar incidents in Greenville recently, but that the city's boat ramp on the MS river was vandalized with the n-word on September 11. "It shouldn't happen in 2016".
Scorched Miss. Church Vandalized With 'Vote Trump' Message
"The act that has happened has left our hearts broken but we are strong together", Hudson said. "Vote Trump" was spray-painted on an outside wall of the church.
"We're very cautious in this climate, in this day and time", Simmons said, "to make sure we're very deliberate in investigating matters like this". It had been there over 111 years. "We're not angry, but we are sad".
She added that the church plans to rebuild in the same location.
Clarion-Ledger reporter Therese Apel posted a statement on Twitter confirming that the Federal Bureau of Investigation is already investigating the situation.
Investigators continue to collect evidence, and while there are no suspects yet, police are "possibly talking to a person of interest", Greenville Police Chief Delando Wilson said at the news conference.
"It tries to push your beliefs on someone else, and this is a predominantly black church and no one has a right to try to influence the way someone votes in this election".