After the cast took a final curtain call, Miranda went backstage and took a pair of scissors to chop off his signature long hair, as reported on People.
And Odom, who won the Tony for Actor in a Leading Role in a Musical for playing Aaron Burr, posted a photo of his wife, Nicolette Robinson, in his dressing room as a goodbye.
The world turned upside down for "Hamilton" fans when the main cast trio announced they were leaving the show.
Meanwhile, Miranda kept his farewell tweets simple, posting just before the show started, "Okay". He had tweeted, "Okay see you on the marquee". The 26-year-old actress, whose performance as Eliza Schuyler earned her a Tony nomination for best leading actress added, "I will cherish #Hamilton and everyone (at) the (Richard Rodgers) Theatre".
During the show, the audience was in a frenzy, giving several standing ovations after solo numbers from the cast, said Jennifer Pelowitz, who came in from New Mexico and had also randomly picked the date. "Til next time, folks!"
"The most profound legacy of #HamiltonBway will be that it has set a table for strangers to connect, to have meaningful conversations".
Just 15 minutes after his exit, Miranda sent a Twitter message suggesting that the show will continue to thrive without him in the title role.
Whether you love or hate the #Hamilcut, you have to admit that it's the end of an era. He'll also star in the forthcoming Mary Poppins sequel opposite Emily Blunt in a new role that is not Dick Van Dyke's chimney sweep Bert.
Miranda confirmed to the New York Times in June that he planned to cut his trademark hair, which he grew out to play Alexander Hamilton, after his run on the broadway show was over.