But after a decade of flickering greatness, he remains a player who divides opinion.
While Arsene Wenger's side have built a reputation for flair and attacking football over the years, they have also found it hard to maintain a title challenge, with critics pointing to fragile defending and a lack of grit.
The Gunners boss will hope they can make the most of their home advantage, his side having lost only once at the Emirates in the league all season.
Monreal has played in 83 Premier League games overall and made 113 appearances across all competitions, scoring two goals including an incredible strike at Manchester United which helped fire Arsenal to the FA Cup Semi-Final previous year.
Speaking about the milestone, Wenger was effusive in his praise of the player.
"It's very hard to find, that intelligence and the timing of his movement", Wenger said. "He always had pace and his movement off the ball was always flawless".
Nacho Monreal: Arsenal left-back signs new long-term contract
"With the amount of teams that could potentially win this league, it's probably going to be the most exciting Premier League for a neutral ever, I think".
Yes, yes, we know you love Mesut Ozil and Alexis Sanchez, but perhaps there are actually other Arsenal players out there who are more deserving of your affection - players like Nacho Monreal.
"He has a very positive attitude", the Frenchman added.
"Early impressions? He likes to put a tackle in, that's for sure", laughs Walcott. "That's where a good player becomes a great player or just remains a good player". "The acid test is that they miss him hugely when he's not playing". Ask the question has Walcott fulfilled his Arsenal potential when he is 30, not when he is just beginning to reach his peak years.
Arsenal have a number of young players that could benefit from loan spells in the Championship, while there are some longer-tenured Gunners that might be looking for a fresh challenge long term. However, with Gibbs' development being hindered by injury in recent seasons, Monreal has come to the fore. "For these reasons I extended my contract", he said.
Arsenal have not won the title since the 2003-04 campaign.