Gaga is nominated for her role on Ryan Murphy's American Horror Story: Hotel, in which she stars as the bloodthirsty hotel owner Countess Elizabeth.
Gervais made jokes about celebrities who were in the room, and some who were absent from the occasion, including Caitlyn Jenner, nominee Jeffrey Tambor, Jennifer Lawrence and previous hosts Tina Fey and Amy Poehler. Their Oscar predictive power, though, is nonexistent.
DiCaprio was the penultimate victor when he was named best actor in a motion picture drama for his portrayal of fur trapper Hugh Glass in revenge epic The Revenant. We have been waiting all night to see Gaga, considering this is the first time she has ever been nominated for a Golden Globe. "Not even Sean Penn will find me", he said, referring to the revelation that the actor met and interviewed the Mexican drug cartel kingpin Joaquin "El Chapo" Guzman.
Thanking her fellow cast members, Lady Gaga said: "Because of you I was able to shine I guess, thank you for sharing your talent with me".
In his acceptance speech Sunday, Damon noted that 18 years have passed since he was at the Beverly Hilton accepting his first Globe for best motion picture screenplay with friend Ben Affleck, with whom he wrote "Good Will Hunting".
I caught it last night and it was beyond wonderful.
Rising star Brie Larson, 26, beat veteran Cate Blanchett to win best drama actress for her role as a young woman held captive for years with a young son in "Room", while Lawrence won best comedy actress for "Joy", about the Miracle Mop inventor.
"The Revenant" was a revelation at the Golden Globes, taking home three major wins including Best Drama, Best Director and Best Actor for Leonardo DiCaprio.
In the Television section of the awards, Mr. Robot pipped Game of Thrones to win in the Drama category, while Mozart in the Jungle took the prize in the Musical or Comedy category.